ORGANIC AND BIOINORGANIC SYNTHESIS

Modern organic synthesis is increasingly driven by the pursuit of functionality, particularly in the areas of total synthesis and method development. The synthesis of complex natural products not only addresses structurally intricate molecules but also aims to produce compounds with promising medicinal properties for further biological investigations. Reaction discovery and development play a pivotal role in enabling efficient synthetic routes to construct key motifs commonly found in medicinal compounds and functional materials. The convergence of these two fields highlights the significance of developing new synthetic methodologies that support both fundamental research and practical applications.

Bioinorganic synthesis is a fundamental aspect of chemical research that employs diverse techniques and methodologies to produce metal-based compounds with potential applications in various fields. The synthesis of bioinorganic compounds often demands extreme conditions, including high temperatures, elevated pressures, multi-step reactions, and meticulous handling to achieve the desired products. Overcoming thermodynamic and kinetic barriers is crucial to ensuring the successful formation of target compounds. The integration of experimental methods with quantum chemical calculations provides a powerful approach to predicting, designing, and optimizing the synthesis of new compounds under the most suitable conditions.

Our laboratory is actively engaged in bioinorganic synthesis, focusing on the preparation, characterization, and exploration of new compounds for potential applications. The research spans multidisciplinary areas, particularly within biological inorganic chemistry and catalysis. Our primary interests include the design and synthesis of novel ligands as chelating agents, the preparation of metal complexes, and the investigation of their structural, physical, and chemical properties. We aim to identify and modify compounds based on their atomic and ionic arrangements to enhance their functionality. The laboratory also specializes in single crystal growth, enzyme inhibition, and antimicrobial activity studies. Collaborative computational studies are pursued to support experimental findings and predict reactivity. Additionally, we explore the catalytic potential of metal complexes, particularly in C-C cross-coupling reactions, for their applications in green chemistry and pharmaceutical synthesis.